service items
1. In silicon Prediction
The self-built data platform and the public standard database were used to query the similarity compounds, and the QSAR method and the validation model were used to quickly predict the chemical, toxic and metabolic characteristics of the compounds. The service contents are as follows:
• Database virtual screening
• Physicochemical prediction
• Metabolic prediction
• Health impact prediction
• Environmental effect prediction
2. In Vitro Screening
Through high-throughput screening platform, cell culture and molecular biology methods were applied to rapidly screen the toxicity of compounds. The mechanism of drug discovery toxicity was studied to determine the critical path of toxicity. The content of the service is as follows:
• High content cell effect screening
• High throughput cytotoxicity screening
• Acute toxicity and genotoxicity
• Reproductive toxicity and EDC screening
• Target organ toxicity screening
3. In Vivo Screening
Model organisms such as rodents, zebrafish and transgenic organisms were used to screen compounds for toxicity. In vivo screening is to further verify the results of computer prediction and cell screening, to exclude the false positive results of screening, and to provide a reference for the pre-test of registered GLP test. The model creatures used are as follows:
• Acute rodent toxicity
• Aquatic toxicity screening
• Model animal toxicity screening
• Toxicity mechanism study
Application Field
In the research and development stage, through safety screening, a preliminary risk forecast is made to help enterprises make risk decisions. Service for chemical registration assessment through QSAR and cross-reading. Relying on computer prediction, cell culture methods and high-throughput screening platforms, key toxicity events are identified, MOA and AOP pathways are established, and material risks are accurately assessed.
Computer Risk Forecasting
Toxicity Mechanism MOA Identification
AOP Adverse Effect Outcome Establishment
Application Field
In the research and development stage, through safety screening, a preliminary risk forecast is made to help enterprises make risk decisions. Service for chemical registration assessment through QSAR and cross-reading. Relying on computer prediction, cell culture methods and high-throughput screening platforms, key toxicity events are identified, MOA and AOP pathways are established, and material risks are accurately assessed.
Computer Risk Forecasting
Toxicity Mechanism MOA Identification
AOP Adverse Effect Outcome Establishment
