The development of green new chemicals requires early toxicity identification to prevent risks. Existing chemical assessment requires rapid toxicity prediction to reduce the use of animals, use new technologies to improve the accuracy of assessment, and overcome the long period of traditional methods and the uncertainty of extrapolation. Based on the computer-aided screening, in vitro cell screening and in vivo animal screening experimental systems, the institute establishes hierarchical screening strategies to predict and screen the physical and chemical properties, ADME properties, toxicology and environmental effects of compounds and small biological molecules. Through the prediction of hazard endpoints such as CMR\EDC\PBT, it is possible to quickly grade the toxicity of substances. Combined with calculation model exposure risk assessment, it serves to establish high-risk priority management substances.