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Toxicity Screening

  The development of green new chemicals requires early toxicity identification to prevent risks. Existing chemical assessment requires rapid toxicity prediction to reduce the use of animals, use new technologies to improve the accuracy of assessment, and overcome the long period of traditional methods and the uncertainty of extrapolation. Based on the computer-aided screening, in vitro cell screening and in vivo animal screening experimental systems, the institute establishes hierarchical screening strategies to predict and screen the physical and chemical properties, ADME properties, toxicology and environmental effects of compounds and small biological molecules. Through the prediction of hazard endpoints such as CMR\EDC\PBT, it is possible to quickly grade the toxicity of substances. Combined with calculation model exposure risk assessment, it serves to establish high-risk priority management substances.


service items

1. In silicon Prediction

The self-built data platform and the public standard database were used to query the similarity compounds, and the QSAR method and the validation model were used to quickly predict the chemical, toxic and metabolic characteristics of the compounds. The service contents are as follows:

•   Database virtual screening

•   Physicochemical prediction

•   Metabolic prediction

•   Health impact prediction

•   Environmental effect prediction

2. In Vitro Screening

Through high-throughput screening platform, cell culture and molecular biology methods were applied to rapidly screen the toxicity of compounds. The mechanism of drug discovery toxicity was studied to determine the critical path of toxicity. The content of the service is as follows:

•   High content cell effect screening

•   High throughput cytotoxicity screening

•   Acute toxicity and genotoxicity

•   Reproductive toxicity and EDC screening

•   Target organ toxicity screening

3. In Vivo Screening

Model organisms such as rodents, zebrafish and transgenic organisms were used to screen compounds for toxicity. In vivo screening is to further verify the results of computer prediction and cell screening, to exclude the false positive results of screening, and to provide a reference for the pre-test of registered GLP test. The model creatures used are as follows:

•   Acute rodent toxicity

•   Aquatic toxicity screening

•   Model animal toxicity screening

•   Toxicity mechanism study

 


Application Field

 

In the research and development stage, through safety screening, a preliminary risk forecast is made to help enterprises make risk decisions. Service for chemical registration assessment through QSAR and cross-reading. Relying on computer prediction, cell culture methods and high-throughput screening platforms, key toxicity events are identified, MOA and AOP pathways are established, and material risks are accurately assessed.

 

Computer Risk Forecasting

 

Toxicity Mechanism MOA Identification

 

AOP Adverse Effect Outcome Establishment



Application Field

 

In the research and development stage, through safety screening, a preliminary risk forecast is made to help enterprises make risk decisions. Service for chemical registration assessment through QSAR and cross-reading. Relying on computer prediction, cell culture methods and high-throughput screening platforms, key toxicity events are identified, MOA and AOP pathways are established, and material risks are accurately assessed.

 

Computer Risk Forecasting

 

Toxicity Mechanism MOA Identification

 

AOP Adverse Effect Outcome Establishment



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